Loperamide abuse and cardiotoxicity
نویسندگان
چکیده
With increasing restrictions and safety protocols implemented in prescribing opioids, there has been an increased incidence of recreational abuse of over-thecounter medications, including loperamide. Loperamide is a peripherally-acting μ-opioid receptor agonist in the gastrointestinal tract which, if taken at high doses, can cross the blood-brain barrier to produce euphoria and analgesia effects.
منابع مشابه
Loperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015.
STUDY OBJECTIVE With the increasing amount of information available on the Internet describing techniques for using loperamide either for self-treatment of opioid withdrawal syndromes or for recreational use (so-called legal highs), the objective was to describe a statewide poison control system's experience with loperamide misuse and abuse, with specific interest in cases of cardiotoxicity, an...
متن کاملVentricular fibrillation due to overdose of loperamide, the “poor man’s methadone”
Loperamide is an over-the-counter antidiarrheal agent that is considered by many patients to be safe, but has been used as a drug of abuse due to its opioid properties. However, cardiotoxicity has been reported, prompting the FDA to release a warning regarding the arrhythmogenic potential of loperamide. We present a case of a 38-year-old female presenting with cardiac arrest thought to be secon...
متن کاملA commentary on operamide and cardiotoxicity
The Letter uncovers an issue which is increasingly relevant in Community Hospital practice. The authors have highlighted the following points with an interesting case and adequate referencing, but the points are relatively well reported and not novel. There has been a clearly documented increase in the number of reported cases of loperamide abuse and toxicity in the literature in recent years. ...
متن کاملNotes from the Field: Cardiac Dysrhythmias After Loperamide Abuse - New York, 2008-2016.
Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties. Recommended over-the-counter doses (range = 2-8 mg daily) do not produce opioid effects in the central nervous system because of poor oral bioavailability and P-glycoprotein efflux* of the medication (1); recent reports suggest that large doses (50-300 mg) of loperamide produce euphoria, central nervous sys...
متن کاملERRATUM: Unexpected Serious Cardiac Arrhythmias in the Setting of Loperamide Abuse.
Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea. When ingested in excessive doses, loperamide can penetrate the blood-brain barrier and is reported to produce euphoria, central nervous system and respiratory depression, and cardiotoxicity. There is an emerging trend in its use among drug abusers for its euphoric effects...
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2017